A Forward Chemical Screen Using Zebrafish Embryos with Novel 2-Substituted 2H-Chromene Derivatives
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چکیده
منابع مشابه
Cinnamyl 2-oxo-2H-chromene-3-carboxylate
The title compound, C(19)H(14)O(4), was prepared by the reaction of 2-oxo-2H-chromene-3-acyl chloride with cinnamic alcohol. The whole mol-ecule is not planar, the dihedral angle between the planes of coumarin and benzene rings being 13.94 (4)°, but the plane of the coumarin ring and that of the ester group are almost coplanar, making a dihedral angle of 2.9 (1)°. In the crystal structure, weak...
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The title compound, C(20)H(24)O(4), was synthesized from the reaction of 2-oxo-2H-chromene-3-acyl chloride and menthol. The mean plane of the ester group and that of the four essentially planar (maximum deviation 0.0112 Å) C atoms of the chair-form cyclo-hexyl ring form dihedral angles of 43.8 (3) ° and 81.8 (1)°, respectively, with the mean plane of the coumarin ring system. In the crystal str...
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BACKGROUND Retinoids regulate key developmental pathways throughout life, and have potential uses for differentiation therapy. It should be possible to identify novel retinoids by coupling new chemical reactions with screens using the zebrafish embryonic model. PRINCIPAL FINDINGS We synthesized novel retinoid analogues and derivatives by amide coupling, obtaining 80-92% yields. A small librar...
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The title compound, C(11)H(8)O(4), features an almost planar mol-ecule (r.m.s. deviation = 0.033 Å for all non-H atoms). In the crystal, the mol-ecules are linked via C-H⋯O hydrogen bonds, forming two-dimensional networks lying parallel to (1-21).
متن کامل2-Ferrocenyl-3-nitro-2H-chromene
In the title compound, [Fe(C5H5)(C14H10NO3)], the cyclo-penta-dienyl rings are in an eclipsed conformation and the pyran ring adopts a half-chair conformation. The mean plane of the pyran ring makes dihedral angles of 79.33 (1) and 80.73 (1)°, respectively, with the substituted and unsubstituted cyclo-penta-dienyl rings. In the crystal, pairs of C-H⋯O hydrogen bonds link the mol-ecules into inv...
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ژورنال
عنوان ژورنال: Chemical Biology & Drug Design
سال: 2009
ISSN: 1747-0277,1747-0285
DOI: 10.1111/j.1747-0285.2009.00782.x